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5月16日工学院生物医学工程系学术报告


题 目: Piezoelectric Materials and Sensors Development for Biomedical Applications
 
报告人:Prof. Wei-Heng Shih
School of Biomedical Engineering, Science, and Health Systems, and Department of Materials Science & Engineering, Drexel University, Philadelphia, USA
 
时  间:2007年5月16日(星期三) 上午10:00
 
地  点:北京大学廖凯原楼212房间
 
主持人:马宏伟
 
联系人:澳门在线威尼斯官方生物医学工程系 陈海峰 (Tel. 6275-4396)
 
欢迎感兴趣者参加!
 
Abstract:
Detection of pathogenic species such as molecules, proteins, virus, and cells is critical to the prevention and diagnosis of diseases. We have developed piezoelectric microcantilever sensors (PEMS) that offer the advantages of in-situ, direct, and simple electrical detection and better capabilities to withstand damping in aqueous environment. Binding of antigens to the antibody immobilized on the cantilever surface increases the cantilever’s mass and reduces its resonance frequency, which is detected by monitoring the resonance frequency shift. Demonstration of in-situ detection of cells, proteins, and specific antigen-antibody binding have been shown using lead zirconate titanate (PZT)/stainless steel cantilevers of less than 0.5 mm in length with picogram sensitivity. Furthermore, as illustrated by experimental and theoretical results, a cantilever’s mass detection sensitivity increased dramatically with a decreasing cantilever size.
More recently, using a precursor solution coating approach we generated highly reactive lead magnesium niobate-lead titanate (PMN-PT) freestanding films that have enhanced piezoelectric response at high electric field. Those films were used to develop miniaturized, highly piezoelectric lead magnesium niobate-lead titanate (PMN-PT) array PEMS with better than 10-14 g/Hz detection sensitivity for proteins including prostate specific antigen (PSA) and human epidermal growth factor receptor 2 (HER2), and bioagent (anthrax spore). Furthermore, we have developed PEMS in the scale of micron using semiconductor microfabrication technique capable of better than 10-16 g/Hz sensitivity.
 
PERSONAL INFORMATION
Date of Birth: February 3, 1954
Citizenship: USA
President of Chinese Cultural Association of Greater Philadelphia, 1999-2001, 2002-2004
Principal of Main Line Chinese School, 2001-2002
 
EDUCATION
Ph.D. 1984  Ohio State University, Columbus, Ohio, Department of Physics
B.Sc. 1976  Tsing-Hua University, Hsinchu, Taiwan, ROC, Department of Physics
 
POSITIONS HELD
Professor                                    Dept. of Materials Science & Engineering    9/1/03-present
                                                  Drexel University
Associate Professor                     Dept. of Materials Engineering                    9/1/96-8/31/03
                                                  Drexel University
Visiting Researcher                     Catalytic Systems Division                          7/1/98-3/31/99
 (Sabbatical leave)                      Johnson Matthey, Wayne, PA
Visiting Associate Professor        Dept. of Applied Chem. and Chem. Eng.     6/97-8/97
                                                  Kagoshima University, Japan
Visiting Associate Professor        National Taiwan University, Taiwan            8/97
Assistant Professor                      Dept. of Materials Engineering                    4/1/91-8/31/96
                                                  Drexel University
Visiting Summer Faculty            Naval Air Warfare Center, Warminster, PA  7/93-9/93
Research Scientist                       Dept. of Materials Science & Engineering    9/87-3/91
                                                  University of Washington, Seattle, WA
Visiting Researcher                     Academia Sinica, Taipei, Taiwan                 12/88-2/89
Postdoctoral Research Associate  Dept. of Physics, University of Washington 1985-1987
Postdoctoral Research Associate  Dept. of Physics, Ohio State University       1984-1985

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